| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKM |
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| Ligand | BDBM50271055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1709641 (CHEMBL4119690) |
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| IC50 | 15660±n/a nM |
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| Citation |  Ning, X; Qi, H; Li, R; Li, Y; Jin, Y; McNutt, MA; Liu, J; Yin, Y Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase. Eur J Med Chem138:343-352 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKM |
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| Name: | Pyruvate kinase PKM |
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| Synonyms: | KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2) |
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| Type: | Protein |
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| Mol. Mass.: | 57944.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14618 |
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| Residue: | 531 |
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| Sequence: | MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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| BDBM50271055 |
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| n/a |
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| Name | BDBM50271055 |
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| Synonyms: | CHEMBL4130279 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27NO2S2 |
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| Mol. Mass. | 377.564 |
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| SMILES | CCCN(CCC)C(=S)SCc1cc(OC)c2ccccc2c1OC |
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| Structure | 
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