| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Egl nine homolog 1 |
|---|
| Ligand | BDBM242558 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1712015 (CHEMBL4122064) |
|---|
| IC50 | 18±n/a nM |
|---|
| Citation |  Hamada, M; Takayama, T; Shibata, T; Hiratate, A; Takahashi, M; Yashiro, M; Takayama, N; Okumura-Kitajima, L; Koretsune, H; Kajiyama, H; Naruse, T; Kato, S; Takano, H; Kakinuma, H Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia. Bioorg Med Chem Lett28:1725-1730 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Egl nine homolog 1 |
|---|
| Name: | Egl nine homolog 1 |
|---|
| Synonyms: | EGLN1_RAT | Egln1 | Hypoxia-inducible factor (HIF-PH2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36098.74 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P59722 |
|---|
| Residue: | 338 |
|---|
| Sequence: | PRAQPAPAQPRVAPPPGGAPGAARAGGAARRGDSSTAASRVPGPEDATQAGSGPGPAEPS
SEDPPPSRSPGPERASLCPAGGGPGEALSPSGGLRPNGQTKPLPALKLALEYIVPCMNKH
GICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPG
CETIGLLMSSMDDLIRHCSGKLGNYRINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVT
CIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYA
ITVWYFDADERARAKVKYLTGEKGVRVELKPNSVSKDV
|
|
|
|---|
| BDBM242558 |
|---|
| n/a |
|---|
| Name | BDBM242558 |
|---|
| Synonyms: | US9422240, 1-353 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18ClN3O6 |
|---|
| Mol. Mass. | 431.826 |
|---|
| SMILES | OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O |c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
