Ki Summary

Reaction Details

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Target

Cysteinyl leukotriene receptor 1

Ligand

BDBM50013919

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_52377 (CHEMBL663210)

IC50

3.1±n/a nM

Citation

Gauthier, JY; Jones, T; Champion, E; Charette, L; Dehaven, R; Ford-Hutchinson, AW; Hoogsteen, K; Lord, A; Masson, P; Piechuta, H Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist. J Med Chem33:2841-5 (1990) [PubMed]

More Info.:

Get all data from this article, Assay Method

Cysteinyl leukotriene receptor 1

Name:

Cysteinyl leukotriene receptor 1

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38565.16

Organism:

Homo sapiens (Human)

Description:

Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271

Residue:

337

Sequence:

MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV

BDBM50013919

n/a

Name

BDBM50013919

Synonyms:

3-[{3-[2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionic acid | CHEMBL97257

Type

Small organic molecule

Emp. Form.

C26H27ClN2O3S2

Mol. Mass.

515.087

SMILES

CN(C)C(=O)CCS[C@@H](SCCC(O)=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1

Structure