| Reaction Details |
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 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Ligand | BDBM50273373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1712875 (CHEMBL4122924) |
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| IC50 | 21±n/a nM |
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| Citation |  Schlapbach, A; Revesz, L; Pissot Soldermann, C; Zoller, T; Régnier, CH; Bornancin, F; Radimerski, T; Blank, J; Schuffenhauer, A; Renatus, M; Erbel, P; Melkko, S; Heng, R; Simic, O; Endres, R; Wartmann, M; Quancard, J N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity. Bioorg Med Chem Lett28:2153-2158 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
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| Type: | Enzyme |
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| Mol. Mass.: | 92257.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UDY8 |
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| Residue: | 824 |
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| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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| BDBM50273373 |
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| n/a |
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| Name | BDBM50273373 |
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| Synonyms: | CHEMBL4129385 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21Cl2N7O2 |
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| Mol. Mass. | 474.343 |
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| SMILES | CNC(=O)c1ncn(n1)-c1ccc(NC(=O)C2CCN(CC2)c2ncccc2Cl)cc1Cl |
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| Structure | 
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