| Reaction Details |
|---|
 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
|---|
| Ligand | BDBM197160 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1714522 (CHEMBL4124571) |
|---|
| EC50 | 7.2±n/a nM |
|---|
| Citation |  Cao, W; Fang, L; Teng, S; Chen, H; Wang, Z Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity. Bioorg Med Chem Lett28:2229-2233 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| L-lactate dehydrogenase A chain |
|---|
| Name: | L-lactate dehydrogenase A chain |
|---|
| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36694.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00338::PDB Code: 4ajp |
|---|
| Residue: | 332 |
|---|
| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
|
|
|
|---|
| BDBM197160 |
|---|
| n/a |
|---|
| Name | BDBM197160 |
|---|
| Synonyms: | GNE-140 (6) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23ClN2O3S2 |
|---|
| Mol. Mass. | 499.045 |
|---|
| SMILES | OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |r,c:1| |
|---|
| Structure | 
|
|---|
Search and Browse
