Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50014706 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54597 (CHEMBL667320) |
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Ki | 0.005500±n/a nM |
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Citation | DeGraw, JI; Christie, PH; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins. J Med Chem33:212-5 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_MOUSE | Dhfr |
Type: | Enzyme |
Mol. Mass.: | 21608.82 |
Organism: | Mus musculus (Mouse) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50014706 |
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n/a |
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Name | BDBM50014706 |
Synonyms: | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid | CHEMBL302068 |
Type | Small organic molecule |
Emp. Form. | C22H25N7O5 |
Mol. Mass. | 467.4778 |
SMILES | CCC(Cc1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O)c1cnc2nc(N)nc(N)c2n1 |
Structure |
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