| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Ligand | BDBM50276375 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1715618 (CHEMBL4125667) |
|---|
| IC50 | 8400±n/a nM |
|---|
| Citation |  Goto, K; Ideo, H; Tsuchida, A; Hirose, Y; Maruyama, I; Noma, S; Shirai, T; Amano, J; Mizuno, M; Matsuda, A Synthesis of 1,5-Anhydro-d-fructose derivatives and evaluation of their inflammasome inhibitors. Bioorg Med Chem26:3763-3772 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Name: | NACHT, LRR and PYD domains-containing protein 3 |
|---|
| Synonyms: | Cias1 | Cias1 | Cold autoinflammatory syndrome 1 protein homolog | Cryopyrin | Mast cell maturation-associated-inducible protein 1 | Mmig1 | NACHT, LRR and PYD domains-containing protein 3 | NLRP3_MOUSE | Nalp3 | Nlrp3 | PYRIN-containing APAF1-like protein 1 | Pypaf1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 118281.75 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_116758 |
|---|
| Residue: | 1033 |
|---|
| Sequence: | MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYL
SRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQERE
HELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWA
LGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGF
DELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDH
PRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQ
QMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILF
EECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGET
VRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMD
HVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNC
CLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLS
HQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSAC
CQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSA
LTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLST
ILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQE
EKPELTIVFEISW
|
|
|
|---|
| BDBM50276375 |
|---|
| n/a |
|---|
| Name | BDBM50276375 |
|---|
| Synonyms: | CHEMBL4129407 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H22O4 |
|---|
| Mol. Mass. | 254.3221 |
|---|
| SMILES | CCCCCCCC(=O)OC[C@H]1OCC(=O)C=C1 |r,c:16| |
|---|
| Structure | 
|
|---|
Search and Browse
