| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Perforin-1 |
|---|
| Ligand | BDBM50276521 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1715818 (CHEMBL4130818) |
|---|
| IC50 | 1320±n/a nM |
|---|
| Citation |  Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Huttunen, KM; Jaiswal, JK; Denny, WA; Akhlaghi, H; Browne, KA; Trapani, JA Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. Eur J Med Chem137:139-155 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Perforin-1 |
|---|
| Name: | Perforin-1 |
|---|
| Synonyms: | PERF_HUMAN | PFP | PRF1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 61392.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1285138 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
|
|
|
|---|
| BDBM50276521 |
|---|
| n/a |
|---|
| Name | BDBM50276521 |
|---|
| Synonyms: | CHEMBL4159529 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H17Cl2N3O3S2 |
|---|
| Mol. Mass. | 530.446 |
|---|
| SMILES | CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
