Compile Data Set for Download or QSAR

Found 341 hits with Last Name = 'browne' and Initial = 'ka'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50137357 (CHEMBL3754633) Show SMILES NC(=O)c1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H13NO3S/c20-18(21)12-3-1-11(2-4-12)16-7-8-17(24-16)13-5-6-15-14(9-13)10-23-19(15)22/h1-9H,10H2,(H2,20,21)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361411 (CHEMBL1934375) Show SMILES O=C1NC(=S)NC1=Cc1csc(n1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C15H9N3O3S2/c19-12-11(17-15(22)18-12)4-9-6-23-13(16-9)7-1-2-10-8(3-7)5-21-14(10)20/h1-4,6H,5H2,(H2,17,18,19,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361419 (CHEMBL1934383) Show SMILES O=C1NC(=S)NC1=Cc1cc2ccc(cc2[nH]1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H13N3O3S/c24-18-17(22-20(27)23-18)8-14-6-12-2-1-11(7-16(12)21-14)10-3-4-15-13(5-10)9-26-19(15)25/h1-8,21H,9H2,(H2,22,23,24,27)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361417 (CHEMBL1934381) Show SMILES O=C1NC(=S)NC1=Cc1cc2ccc(cc2s1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H12N2O3S2/c23-18-16(21-20(26)22-18)8-14-6-12-2-1-11(7-17(12)27-14)10-3-4-15-13(5-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,26)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361406 (CHEMBL1934370) Show SMILES O=C1NC(=S)NC1=Cc1ccc(cn1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C17H11N3O3S/c21-15-14(19-17(24)20-15)6-12-3-1-10(7-18-12)9-2-4-13-11(5-9)8-23-16(13)22/h1-7H,8H2,(H2,19,20,21,24)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361433 (CHEMBL1934397) Show SMILES O=[#6]-1-[#8]-[#6]-c2cc(ccc-12)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=S)-[#7]-[#6]-2=O)s1 Show InChI InChI=1S/C17H10N2O4S2/c20-14-12(15(21)19-17(24)18-14)6-10-2-4-13(25-10)8-1-3-11-9(5-8)7-23-16(11)22/h1-6H,7H2,(H2,18,19,20,21,24)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445263 (CHEMBL3103651) Show SMILES O=C1NC(=O)\C(N1)=C/c1ccc(s1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C16H11N3O3S/c20-14-11-3-1-8(5-9(11)7-17-14)13-4-2-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361422 (CHEMBL1934386) Show SMILES O=C1NC(=S)NC1=Cc1ccc2cc(ccc2n1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C21H13N3O3S/c25-19-18(23-21(28)24-19)9-15-4-1-13-7-12(3-6-17(13)22-15)11-2-5-16-14(8-11)10-27-20(16)26/h1-9H,10H2,(H2,23,24,25,28)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361416 (CHEMBL1934380) Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2s1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H12N2O3S2/c23-18-16(21-20(26)22-18)8-14-7-12-5-11(2-4-17(12)27-14)10-1-3-15-13(6-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,26)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445286 (CHEMBL3103907) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C17H13N3O2S2/c1-20-8-10-6-9(2-4-12(10)16(20)22)14-5-3-11(24-14)7-13-15(21)19-17(23)18-13/h2-7H,8H2,1H3,(H2,18,19,21,23)/b13-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361418 (CHEMBL1934382) Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2o1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H12N2O4S/c23-18-16(21-20(27)22-18)8-14-7-12-5-11(2-4-17(12)26-14)10-1-3-15-13(6-10)9-25-19(15)24/h1-8H,9H2,(H2,21,22,23,27)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445279 (CHEMBL3103914) Show SMILES OCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O3S2/c23-7-1-6-22-10-12-8-11(2-4-14(12)18(22)25)16-5-3-13(27-16)9-15-17(24)21-19(26)20-15/h2-5,8-9,23H,1,6-7,10H2,(H2,20,21,24,26)/b15-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445276 (CHEMBL3103917) Show SMILES CCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H15N3O4S2/c1-2-26-19(25)22-9-11-7-10(3-5-13(11)17(22)24)15-6-4-12(28-15)8-14-16(23)21-18(27)20-14/h3-8H,2,9H2,1H3,(H2,20,21,23,27)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445285 (CHEMBL3103908) Show SMILES CCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O2S2/c1-2-21-9-11-7-10(3-5-13(11)17(21)23)15-6-4-12(25-15)8-14-16(22)20-18(24)19-14/h3-8H,2,9H2,1H3,(H2,19,20,22,24)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445259 (CHEMBL3103655) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(cn1)-c1ccc2C(=O)NCc2c1 Show InChI InChI=1S/C17H12N4O2S/c22-15-13-4-2-9(5-11(13)8-19-15)10-1-3-12(18-7-10)6-14-16(23)21-17(24)20-14/h1-7H,8H2,(H,19,22)(H2,20,21,23,24)/b14-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445267 (CHEMBL3103647) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CCNC(=O)c2c1 Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-7-10(2-1-9(12)5-6-18-15)14-4-3-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50137379 (CHEMBL3754407) Show SMILES NC(=O)c1ccc(cc1O)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H13NO4S/c20-18(22)14-4-2-11(8-15(14)21)17-6-5-16(25-17)10-1-3-13-12(7-10)9-24-19(13)23/h1-8,21H,9H2,(H2,20,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276535 (CHEMBL4169732) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C25H19N3O5S2/c1-28-14-18-10-16(4-7-21(18)24(28)29)22-8-9-23(34-22)17-11-19(13-26-12-17)27-35(32,33)20-5-2-15(3-6-20)25(30)31/h2-13,27H,14H2,1H3,(H,30,31)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445280 (CHEMBL3103913) Show SMILES OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H15N3O3S2/c22-6-5-21-9-11-7-10(1-3-13(11)17(21)24)15-4-2-12(26-15)8-14-16(23)20-18(25)19-14/h1-4,7-8,22H,5-6,9H2,(H2,19,20,23,25)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361400 (CHEMBL1934364) Show SMILES O=C1NC(=S)NC1=Cc1ccc(s1)-c1ccc2C(=O)OCc2c1 |w:7.8| Show InChI InChI=1S/C16H10N2O3S2/c19-14-12(17-16(22)18-14)6-10-2-4-13(23-10)8-1-3-11-9(5-8)7-21-15(11)20/h1-6H,7H2,(H2,17,18,19,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445303 (CHEMBL3102870) Show SMILES NC(=O)c1cccc(c1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H11N3O2S2/c16-13(19)9-3-1-2-8(6-9)12-5-4-10(22-12)7-11-14(20)18-15(21)17-11/h1-7H,(H2,16,19)(H2,17,18,20,21)/b11-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361432 (CHEMBL1934396) Show SMILES O=[#6]-1-[#8]-[#6]-c2cc(ccc-12)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)s1 |w:13.15| Show InChI InChI=1S/C17H10N2O5S/c20-14-12(15(21)19-17(23)18-14)6-10-2-4-13(25-10)8-1-3-11-9(5-8)7-24-16(11)22/h1-6H,7H2,(H2,18,19,20,21,23)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361420 (CHEMBL1934384) Show SMILES O=C1NC(=S)NC1=Cc1cc2cc(ccc2[nH]1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C20H13N3O3S/c24-18-17(22-20(27)23-18)8-14-7-12-5-11(2-4-16(12)21-14)10-1-3-15-13(6-10)9-26-19(15)25/h1-8,21H,9H2,(H2,22,23,24,27)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50137451 (CHEMBL3753587) Show SMILES OCc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H14O3S/c20-10-12-1-3-13(4-2-12)17-7-8-18(23-17)14-5-6-16-15(9-14)11-22-19(16)21/h1-9,20H,10-11H2	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50137456 (CHEMBL3753271) Show SMILES NC(=O)c1ccc(cn1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C18H12N2O3S/c19-17(21)14-4-2-11(8-20-14)16-6-5-15(24-16)10-1-3-13-12(7-10)9-23-18(13)22/h1-8H,9H2,(H2,19,21)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445277 (CHEMBL3103916) Show SMILES CC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C18H13N3O3S2/c1-9(22)21-8-11-6-10(2-4-13(11)17(21)24)15-5-3-12(26-15)7-14-16(23)20-18(25)19-14/h2-7H,8H2,1H3,(H2,19,20,23,25)/b14-7+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50275059 ((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...) Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12 Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50275059 ((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...) Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12 Show InChI InChI=1S/C17H11NO2S2/c1-9-6-12-13(20-17(19)15(12)16(21)18-9)7-10-8-22-14-5-3-2-4-11(10)14/h2-8H,1H3,(H,18,21)/b13-7-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay				J Med Chem 51: 7614-24 (2009) Article DOI: 10.1021/jm801063n BindingDB Entry DOI: 10.7270/Q24F1QK1
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276462 (CHEMBL4171638) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H16ClF2N3O3S2/c1-30-12-15-8-13(2-4-17(15)24(30)31)20-5-6-21(34-20)14-9-19(23(25)28-11-14)29-35(32,33)22-7-3-16(26)10-18(22)27/h2-11,29H,12H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50347203 (CHEMBL1795754) Show SMILES CNC(=O)c1ccc(cc1)-c1c(C#N)c(N)n2c3ccccc3nc2c1C#N Show InChI InChI=1S/C21H14N6O/c1-25-21(28)13-8-6-12(7-9-13)18-14(10-22)19(24)27-17-5-3-2-4-16(17)26-20(27)15(18)11-23/h2-9H,24H2,1H3,(H,25,28)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...				Bioorg Med Chem 19: 4091-100 (2011) Article DOI: 10.1016/j.bmc.2011.05.013 BindingDB Entry DOI: 10.7270/Q2W66M48
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361401 (CHEMBL1934365) Show SMILES O=C1NC(=S)NC1=Cc1cc(cs1)-c1ccc2C(=O)OCc2c1 |w:7.8| Show InChI InChI=1S/C16H10N2O3S2/c19-14-13(17-16(22)18-14)5-11-4-10(7-23-11)8-1-2-12-9(3-8)6-21-15(12)20/h1-5,7H,6H2,(H2,17,18,19,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276597 (CHEMBL4165670) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2cccs2)c1 Show InChI InChI=1S/C22H17N3O3S3/c1-25-13-16-9-14(4-5-18(16)22(25)26)19-6-7-20(30-19)15-10-17(12-23-11-15)24-31(27,28)21-3-2-8-29-21/h2-12,24H,13H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276547 (CHEMBL4175880) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccccn2)c1 Show InChI InChI=1S/C23H18N4O3S2/c1-27-14-17-10-15(5-6-19(17)23(27)28)20-7-8-21(31-20)16-11-18(13-24-12-16)26-32(29,30)22-4-2-3-9-25-22/h2-13,26H,14H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50137455 (CHEMBL3752189) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H15NO4S2/c1-26(22,23)20-15-5-2-12(3-6-15)17-8-9-18(25-17)13-4-7-16-14(10-13)11-24-19(16)21/h2-10,20H,11H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361431 (CHEMBL1934395) Show SMILES O=C1NC(=O)\C(S1)=C/c1ccc(s1)-c1ccc2C(=O)OCc2c1 |w:8.8| Show InChI InChI=1S/C16H9NO4S2/c18-14-13(23-16(20)17-14)6-10-2-4-12(22-10)8-1-3-11-9(5-8)7-21-15(11)19/h1-6H,7H2,(H,17,18,20)/b13-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445268 (CHEMBL3103646) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2C(=O)NCCc2c1 Show InChI InChI=1S/C17H13N3O2S2/c21-15-12-3-1-10(7-9(12)5-6-18-15)14-4-2-11(24-14)8-13-16(22)20-17(23)19-13/h1-4,7-8H,5-6H2,(H,18,21)(H2,19,20,22,23)/b13-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445307 (CHEMBL3104019) Show SMILES CSc1ccc(cc1)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C15H12N2OS3/c1-20-10-4-2-9(3-5-10)13-7-6-11(21-13)8-12-14(18)17-15(19)16-12/h2-8H,1H3,(H2,16,17,18,19)/b12-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50235190 (CHEMBL4090472) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1 Show InChI InChI=1S/C24H17F2N3O3S2/c1-29-13-16-8-14(2-4-19(16)24(29)30)21-5-6-22(33-21)15-9-18(12-27-11-15)28-34(31,32)23-7-3-17(25)10-20(23)26/h2-12,28H,13H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) assessed as decrease in lysis of 51Cr-labelled human Jurkat cells by measuring 51Cr release prein...				Bioorg Med Chem Lett 27: 1050-1054 (2017) Article DOI: 10.1016/j.bmcl.2016.12.057 BindingDB Entry DOI: 10.7270/Q2XS5XNH
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445281 (CHEMBL3103912) Show SMILES CC(=O)OCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C20H17N3O4S2/c1-11(24)27-7-6-23-10-13-8-12(2-4-15(13)19(23)26)17-5-3-14(29-17)9-16-18(25)22-20(28)21-16/h2-5,8-9H,6-7,10H2,1H3,(H2,21,22,25,28)/b16-9+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445283 (CHEMBL3103910) Show SMILES CCCCN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C20H19N3O2S2/c1-2-3-8-23-11-13-9-12(4-6-15(13)19(23)25)17-7-5-14(27-17)10-16-18(24)22-20(26)21-16/h4-7,9-10H,2-3,8,11H2,1H3,(H2,21,22,24,26)/b16-10+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361429 (CHEMBL1934393) Show SMILES O=C1NC(=O)\C(N1)=C/c1ccc(s1)-c1ccc2C(=O)OCc2c1 |w:8.8| Show InChI InChI=1S/C16H10N2O4S/c19-14-12(17-16(21)18-14)6-10-2-4-13(23-10)8-1-3-11-9(5-8)7-22-15(11)20/h1-6H,7H2,(H2,17,18,19,21)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50137447 (CHEMBL3752776) Show SMILES NC(=O)c1ccc(cc1N)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H14N2O3S/c20-15-8-11(2-4-14(15)18(21)22)17-6-5-16(25-17)10-1-3-13-12(7-10)9-24-19(13)23/h1-8H,9,20H2,(H2,21,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) Article DOI: 10.1016/j.bmcl.2015.12.003 BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276426 (CHEMBL4162248) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1 Show InChI InChI=1S/C25H18F3N3O3S2/c1-31-14-17-9-15(5-6-21(17)24(31)32)22-7-8-23(35-22)16-10-19(13-29-12-16)30-36(33,34)20-4-2-3-18(11-20)25(26,27)28/h2-13,30H,14H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445278 (CHEMBL3103915) Show SMILES OCC(O)CN1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H17N3O4S2/c23-9-12(24)8-22-7-11-5-10(1-3-14(11)18(22)26)16-4-2-13(28-16)6-15-17(25)21-19(27)20-15/h1-6,12,23-24H,7-9H2,(H2,20,21,25,27)/b15-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361412 (CHEMBL1934376) Show SMILES O=C1NC(=S)NC1=Cc1cc(no1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C15H9N3O4S/c19-13-12(16-15(23)17-13)5-9-4-11(18-22-9)7-1-2-10-8(3-7)6-21-14(10)20/h1-5H,6H2,(H2,16,17,19,23)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50275013 ((Z)-1-((1H-Indol-2-yl)methylene)-6-methyl-4-thioxo...) Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1cc2ccccc2[nH]1 Show InChI InChI=1S/C17H12N2O2S/c1-9-6-12-14(21-17(20)15(12)16(22)18-9)8-11-7-10-4-2-3-5-13(10)19-11/h2-8,19H,1H3,(H,18,22)/b14-8-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay				J Med Chem 51: 7614-24 (2009) Article DOI: 10.1021/jm801063n BindingDB Entry DOI: 10.7270/Q24F1QK1
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276521 (CHEMBL4159529) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 Show InChI InChI=1S/C24H17Cl2N3O3S2/c1-29-13-16-8-14(2-4-19(16)24(29)30)22-6-7-23(33-22)15-9-17(12-27-11-15)28-34(31,32)18-3-5-20(25)21(26)10-18/h2-12,28H,13H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50445270 (CHEMBL3103644) Show SMILES O=C1NC(=S)N\C1=C\c1ccc(s1)-c1ccc2CNC(=O)c2c1 Show InChI InChI=1S/C16H11N3O2S2/c20-14-11-5-8(1-2-9(11)7-17-14)13-4-3-10(23-13)6-12-15(21)19-16(22)18-12/h1-6H,7H2,(H,17,20)(H2,18,19,21,22)/b12-6+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50361410 (CHEMBL1934374) Show SMILES O=C1NC(=S)NC1=Cc1nc(cs1)-c1ccc2C(=O)OCc2c1 |w:6.5,8.8| Show InChI InChI=1S/C15H9N3O3S2/c19-13-10(17-15(22)18-13)4-12-16-11(6-23-12)7-1-2-9-8(3-7)5-21-14(9)20/h1-4,6H,5H2,(H2,17,18,19,22)	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin-mediated lysis of Jurkat cells assessed as [51Cr] release preincubated with perforin for 30 mins followed by incub...				Bioorg Med Chem 20: 1319-36 (2012) Article DOI: 10.1016/j.bmc.2011.12.011 BindingDB Entry DOI: 10.7270/Q29C6XW9
					More data for this Ligand-Target Pair
Perforin-1 (Homo sapiens (Human))	BDBM50276527 (CHEMBL4166108) Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2cccc(OC(F)(F)F)c2)c1 Show InChI InChI=1S/C25H18F3N3O4S2/c1-31-14-17-9-15(5-6-21(17)24(31)32)22-7-8-23(36-22)16-10-18(13-29-12-16)30-37(33,34)20-4-2-3-19(11-20)35-25(26,27)28/h2-13,30H,14H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...				Eur J Med Chem 137: 139-155 (2017) Article DOI: 10.1016/j.ejmech.2017.05.048 BindingDB Entry DOI: 10.7270/Q21R6T15
					More data for this Ligand-Target Pair

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