BDBM50137455 CHEMBL3752189

SMILES: CS(=O)(=O)Nc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1

InChI Key: InChIKey=HCEYSZYRKLLAQJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50137455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50137455 (CHEMBL3752189) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 Show InChI InChI=1S/C19H15NO4S2/c1-26(22,23)20-15-5-2-12(3-6-15)17-8-9-18(25-17)13-4-7-16-14(10-13)11-24-19(16)21/h2-10,20H,11H2,1H3	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubati...				Bioorg Med Chem Lett 26: 355-60 (2016) BindingDB Entry DOI: 10.7270/Q2B859ZN
					More data for this Ligand-Target Pair