Reaction Details |
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Target | Perforin-1 |
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Ligand | BDBM50137455 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1549002 (CHEMBL3756437) |
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IC50 | 1090±n/a nM |
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Citation | Miller, CK; Huttunen, KM; Denny, WA; Jaiswal, JK; Ciccone, A; Browne, KA; Trapani, JA; Spicer, JA Diarylthiophenes as inhibitors of the pore-forming protein perforin. Bioorg Med Chem Lett26:355-60 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Perforin-1 |
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Name: | Perforin-1 |
Synonyms: | PERF_HUMAN | PFP | PRF1 |
Type: | PROTEIN |
Mol. Mass.: | 61392.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1285138 |
Residue: | 555 |
Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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BDBM50137455 |
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n/a |
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Name | BDBM50137455 |
Synonyms: | CHEMBL3752189 |
Type | Small organic molecule |
Emp. Form. | C19H15NO4S2 |
Mol. Mass. | 385.457 |
SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1ccc(s1)-c1ccc2C(=O)OCc2c1 |
Structure |
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