Reaction Details |
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Target | Perforin-1 |
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Ligand | BDBM50276547 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1715818 (CHEMBL4130818) |
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IC50 | 1070±n/a nM |
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Citation | Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Huttunen, KM; Jaiswal, JK; Denny, WA; Akhlaghi, H; Browne, KA; Trapani, JA Substituted arylsulphonamides as inhibitors of perforin-mediated lysis. Eur J Med Chem137:139-155 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Perforin-1 |
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Name: | Perforin-1 |
Synonyms: | PERF_HUMAN | PFP | PRF1 |
Type: | PROTEIN |
Mol. Mass.: | 61392.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1285138 |
Residue: | 555 |
Sequence: | MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFP
VDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARD
AARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYS
FHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALR
TCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERH
SEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREAL
RRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVT
FIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRL
QVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ
MLLGEPPGNRSGAVW
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BDBM50276547 |
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n/a |
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Name | BDBM50276547 |
Synonyms: | CHEMBL4175880 |
Type | Small organic molecule |
Emp. Form. | C23H18N4O3S2 |
Mol. Mass. | 462.544 |
SMILES | CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccccn2)c1 |
Structure |
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