| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 2 |
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| Ligand | BDBM50278484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1720163 (CHEMBL4135163) |
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| IC50 | 1430±n/a nM |
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| Citation |  Ji, YY; Lin, SD; Wang, YJ; Su, MB; Zhang, W; Gunosewoyo, H; Yang, F; Li, J; Tang, J; Zhou, YB; Yu, LF Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors. Eur J Med Chem141:101-112 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 2 |
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| Name: | Lysine-specific histone demethylase 2 |
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| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92112.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_992590 |
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| Residue: | 822 |
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| Sequence: | MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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| BDBM50278484 |
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| n/a |
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| Name | BDBM50278484 |
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| Synonyms: | CHEMBL4170687 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23ClN2 |
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| Mol. Mass. | 278.82 |
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| SMILES | Cl.[H][C@]12Cc3ccccc3[C@@]1([H])[C@H]2NCC1CCNCC1 |r| |
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| Structure | 
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