| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknB |
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| Ligand | BDBM50279715 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1721605 (CHEMBL4136605) |
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| Ki | <1.000000±n/a nM |
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| Citation |  Wang, T; Bemis, G; Hanzelka, B; Zuccola, H; Wynn, M; Moody, CS; Green, J; Locher, C; Liu, A; Gao, H; Xu, Y; Wang, S; Wang, J; Bennani, YL; Thomson, JA; Müh, U Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett8:1224-1229 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PknB |
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| Name: | Serine/threonine-protein kinase PknB |
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| Synonyms: | PKNB_MYCTU | pknB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66497.93 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_774233 |
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| Residue: | 626 |
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| Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
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| BDBM50279715 |
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| n/a |
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| Name | BDBM50279715 |
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| Synonyms: | CHEMBL4162544 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13FN6O2S2 |
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| Mol. Mass. | 380.42 |
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| SMILES | NS(=O)(=O)c1ccc(s1)-c1ncc(F)c(Nc2cc([nH]n2)C2CC2)n1 |
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| Structure | 
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