| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknB |
|---|
| Ligand | BDBM50279720 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1721605 (CHEMBL4136605) |
|---|
| Ki | 5.0±n/a nM |
|---|
| Citation |  Wang, T; Bemis, G; Hanzelka, B; Zuccola, H; Wynn, M; Moody, CS; Green, J; Locher, C; Liu, A; Gao, H; Xu, Y; Wang, S; Wang, J; Bennani, YL; Thomson, JA; Müh, U Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett8:1224-1229 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PknB |
|---|
| Name: | Serine/threonine-protein kinase PknB |
|---|
| Synonyms: | PKNB_MYCTU | pknB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66497.93 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | ChEMBL_774233 |
|---|
| Residue: | 626 |
|---|
| Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
|
|
|
|---|
| BDBM50279720 |
|---|
| n/a |
|---|
| Name | BDBM50279720 |
|---|
| Synonyms: | CHEMBL4177229 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H17ClN6 |
|---|
| Mol. Mass. | 400.864 |
|---|
| SMILES | Clc1ccc2nc(nc(Nc3cc([nH]n3)C3CC3)c2c1)-c1ccc(CC#N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
