Ki Summary

Reaction Details

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Target

Signal transducer and activator of transcription 3

Ligand

BDBM50279545

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1721223 (CHEMBL4136223)

IC50

7000±n/a nM

Citation

Ye, XS; He, J; Cheng, YC; Zhang, L; Qiao, HY; Pan, XG; Zhang, J; Liu, SN; Zhang, WK; Xu, JK Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis. J Nat Prod80:3103-3111 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Signal transducer and activator of transcription 3

Name:

Signal transducer and activator of transcription 3

Synonyms:

APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)

Type:

Protein

Mol. Mass.:

88064.31

Organism:

Homo sapiens (Human)

Description:

P40763

Residue:

770

Sequence:

MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM

BDBM50279545

n/a

Name

BDBM50279545

Synonyms:

(7Alpha-Hydroxy)-Morroniside | CHEMBL2152455

Type

Small organic molecule

Emp. Form.

C17H26O11

Mol. Mass.

406.3817

SMILES

[H][C@@]1(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)OC=C(C(=O)OC)[C@@]2([H])C[C@@H](O)O[C@@H](C)[C@@]12[H] |r,t:16|

Structure