| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAS guanyl-releasing protein 1 |
|---|
| Ligand | BDBM50280749 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1722152 (CHEMBL4137152) |
|---|
| EC50 | 3730±n/a nM |
|---|
| Citation |  Ann, J; Czikora, A; Saini, AS; Zhou, X; Mitchell, GA; Lewin, NE; Peach, ML; Blumberg, PM; Lee, J ?-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands. J Med Chem61:6261-6276 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAS guanyl-releasing protein 1 |
|---|
| Name: | RAS guanyl-releasing protein 1 |
|---|
| Synonyms: | CalDAG-GEFII | Calcium and DAG-regulated guanine nucleotide exchange factor II | GRP1_HUMAN | RASGRP | RASGRP1 | Ras guanyl-releasing protein |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90418.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_102739 |
|---|
| Residue: | 797 |
|---|
| Sequence: | MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG
LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK
DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY
YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK
NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA
PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI
SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR
KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ
LEKSNHVLAQMEQGDCS
|
|
|
|---|
| BDBM50280749 |
|---|
| n/a |
|---|
| Name | BDBM50280749 |
|---|
| Synonyms: | CHEMBL4169454 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25NO5 |
|---|
| Mol. Mass. | 371.4269 |
|---|
| SMILES | Cn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
