| Reaction Details |
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 | Report a problem with these data |
| Target | Ras guanyl-releasing protein 3 |
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| Ligand | BDBM50244975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1722136 (CHEMBL4137136) |
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| Ki | 90±n/a nM |
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| Citation |  Ann, J; Czikora, A; Saini, AS; Zhou, X; Mitchell, GA; Lewin, NE; Peach, ML; Blumberg, PM; Lee, J ?-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands. J Med Chem61:6261-6276 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ras guanyl-releasing protein 3 |
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| Name: | Ras guanyl-releasing protein 3 |
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| Synonyms: | GRP3 | GRP3_HUMAN | KIAA0846 | RAS guanyl releasing protein 3 | RASGRP3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78335.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1364407 |
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| Residue: | 690 |
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| Sequence: | MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
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| BDBM50244975 |
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| n/a |
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| Name | BDBM50244975 |
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| Synonyms: | (E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethylene)-tetrahydrofuran-2-yl)methyl 4-methoxybenzoate | CHEMBL470094 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19NO6 |
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| Mol. Mass. | 369.368 |
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| SMILES | COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccccn2)C(=O)O1 |
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| Structure | 
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