Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50015889 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63806 |
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IC50 | >40000±n/a nM |
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Citation | Doherty, JB; Ashe, BM; Barker, PL; Blacklock, TJ; Butcher, JW; Chandler, GO; Dahlgren, ME; Davies, P; Dorn, CP; Finke, PE Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters. J Med Chem33:2513-21 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50015889 |
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n/a |
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Name | BDBM50015889 |
Synonyms: | 3-Acetoxymethyl-7-ethoxy-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester | CHEMBL420595 |
Type | Small organic molecule |
Emp. Form. | C16H23NO6S |
Mol. Mass. | 357.422 |
SMILES | CCO[C@@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C(=O)OC(C)(C)C |c:12| |
Structure |
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