| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50016002 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195779 |
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| IC50 | 19±n/a nM |
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| Citation |  Kempf, DJ; de Lara, E; Stein, HH; Cohen, J; Egan, DA; Plattner, JJ Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites. J Med Chem33:371-4 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50016002 |
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| n/a |
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| Name | BDBM50016002 |
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| Synonyms: | (2R,4R)-[[1-Benzyl-4-(1-cyclohexylmethyl-2-hydroxy-4-isobutylcarbamoyl-pent-4-enylcarbamoyl)-2-hydroxy-nonyl]-carbamic acid tert-butyl ester | CHEMBL122044 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H65N3O6 |
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| Mol. Mass. | 671.9499 |
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| SMILES | CCCCCC(CC(O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=C)C(=O)NCC(C)C |
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| Structure | 
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