| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50284071 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1726779 (CHEMBL4142057) |
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| IC50 | 100±n/a nM |
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| Citation |  Taha, M; Ullah, H; Al Muqarrabun, LMR; Khan, MN; Rahim, F; Ahmat, N; Ali, M; Perveen, S Synthesis of bis-indolylmethanes as new potential inhibitors of ?-glucuronidase and their molecular docking studies. Eur J Med Chem143:1757-1767 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase) |
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| Type: | Protein |
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| Mol. Mass.: | 74736.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 651 |
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| Sequence: | MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
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| BDBM50284071 |
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| n/a |
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| Name | BDBM50284071 |
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| Synonyms: | CHEMBL4165927 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H32N6O8 |
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| Mol. Mass. | 724.7175 |
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| SMILES | Cc1ccc(cc1)C(c1c[nH]c2ccc(cc12)C(=O)N\N=C\c1cc(O)c(O)cc1O)c1c[nH]c2ccc(cc12)C(=O)N\N=C\c1cc(O)c(O)cc1O |
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| Structure | 
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