| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Trifunctional purine biosynthetic protein adenosine-3 |
|---|
| Ligand | BDBM50016659 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_69918 |
|---|
| IC50 | 0.001±n/a nM |
|---|
| Comments | 0.0011 20220121 |
|---|
| Citation |  Nair, MG; Murthy, BR; Patil, SD; Kisliuk, RL; Thorndike, J; Gaumont, Y; Ferone, R; Duch, DS; Edelstein, MP Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase. J Med Chem32:1277-83 (1989) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Trifunctional purine biosynthetic protein adenosine-3 |
|---|
| Name: | Trifunctional purine biosynthetic protein adenosine-3 |
|---|
| Synonyms: | GAR Tfase | GAR transformylase | GART | Glycinamide ribonucleotide formyltransferase (GARFTase) | Glycinamide ribonucleotide transformylase (GAR Tfase) | PGFT | PRGS | PUR2_HUMAN | Thymidylate synthase/GAR transformylase/AICAR transformylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 107768.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22102 |
|---|
| Residue: | 1010 |
|---|
| Sequence: | MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE
|
|
|
|---|
| BDBM50016659 |
|---|
| n/a |
|---|
| Name | BDBM50016659 |
|---|
| Synonyms: | 2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-yl)-2-methyl-propyl]-benzoylamino}-pentanedioic acid | CHEMBL23699 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28N6O6 |
|---|
| Mol. Mass. | 472.4943 |
|---|
| SMILES | CC(CC1CNc2nc(N)[nH]c(=O)c2N1)Cc1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
