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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Ligand | BDBM50286731 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1729499 (CHEMBL4144777) | ||
| IC50 | 6.9±n/a nM | ||
| Citation |  Stepan, AF; Tran, TP; Helal, CJ; Brown, MS; Chang, C; O'Connor, RE; De Vivo, M; Doran, SD; Fisher, EL; Jenkinson, S; Karanian, D; Kormos, BL; Sharma, R; Walker, GS; Wright, AS; Yang, EX; Brodney, MA; Wager, TT; Verhoest, PR; Obach, RS Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189. ACS Med Chem Lett9:68-72 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-dependent 3',5'-cyclic phosphodiesterase | |||
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase | ||
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105691.58 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00408 | ||
| Residue: | 941 | ||
| Sequence: |
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| BDBM50286731 | |||
| n/a | |||
| Name | BDBM50286731 | ||
| Synonyms: | CHEMBL4171712 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H17F3N6O2 | ||
| Mol. Mass. | 418.3725 | ||
| SMILES | Cc1nc(-c2c(CO)nn(C)c2-c2ccc(cc2)C(F)(F)F)n2nc(C)[nH]c(=O)c12 |(21.28,-18.73,;20.8,-17.27,;21.69,-16.02,;20.78,-14.79,;21.25,-13.32,;20.34,-12.07,;18.8,-12.08,;18.02,-10.75,;21.23,-10.82,;22.7,-11.29,;23.94,-10.38,;22.71,-12.83,;23.95,-13.73,;23.8,-15.26,;25.05,-16.16,;26.45,-15.52,;26.6,-13.98,;25.35,-13.09,;27.7,-16.42,;27.55,-17.95,;29.11,-15.79,;29.03,-17.19,;19.33,-15.27,;18,-14.49,;16.67,-15.27,;15.33,-14.5,;16.67,-16.81,;18,-17.57,;18,-19.11,;19.33,-16.8,)| | ||
| Structure | 
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