Reaction Details |
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Target | Diacylglycerol O-acyltransferase 1 |
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Ligand | BDBM50287451 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1729639 (CHEMBL4144917) |
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IC50 | 6.0±n/a nM |
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Citation | Cheung, M; Tangirala, RS; Bethi, SR; Joshi, HV; Ariazi, JL; Tirunagaru, VG; Kumar, S Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1. ACS Med Chem Lett9:103-108 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 1 |
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Name: | Diacylglycerol O-acyltransferase 1 |
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
Type: | Protein |
Mol. Mass.: | 55297.82 |
Organism: | Homo sapiens (Human) |
Description: | O75907 |
Residue: | 488 |
Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM50287451 |
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n/a |
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Name | BDBM50287451 |
Synonyms: | CHEMBL4172357 |
Type | Small organic molecule |
Emp. Form. | C27H25ClN2O4 |
Mol. Mass. | 476.951 |
SMILES | CCC1(CC(O)=O)CCc2cc(ccc2C1=O)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1 |
Structure |
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