Reaction Details |
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Target | Serine/threonine-protein kinase Chk2 |
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Ligand | BDBM50163251 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1731081 (CHEMBL4146617) |
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IC50 | 32±n/a nM |
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Citation | Galal, SA; Khairat, SHM; Ali, HI; Shouman, SA; Attia, YM; Ali, MM; Mahmoud, AE; Abdel-Halim, AH; Fyiad, AA; Tabll, A; El-Shenawy, R; El Abd, YS; Ramdan, R; El Diwani, HI Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors. Eur J Med Chem144:859-873 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk2 |
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Name: | Serine/threonine-protein kinase Chk2 |
Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
Type: | Protein |
Mol. Mass.: | 60908.59 |
Organism: | Homo sapiens (Human) |
Description: | O96017 |
Residue: | 543 |
Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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BDBM50163251 |
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n/a |
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Name | BDBM50163251 |
Synonyms: | 2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imidazole-5-carboxamide | 2-[4-(4-Hydroxy-phenylsulfanyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide | CHEMBL195041 |
Type | Small organic molecule |
Emp. Form. | C20H15N3O2S |
Mol. Mass. | 361.417 |
SMILES | NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1 |
Structure |
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