BDBM50163251 2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imidazole-5-carboxamide::2-[4-(4-Hydroxy-phenylsulfanyl)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide::CHEMBL195041
SMILES: NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1
InChI Key: InChIKey=AYVQDEPKWVWSGO-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase CHK2 (Homo sapiens (Human)) | BDBM50163251 (2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of recombinant human Chk2 kinase | J Med Chem 48: 1873-85 (2005) Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase CHK2 (Homo sapiens (Human)) | BDBM50163251 (2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL | Assay Description Inhibition of human recombinant Chk2 | Bioorg Med Chem Lett 17: 6467-71 (2007) Article DOI: 10.1016/j.bmcl.2007.09.098 BindingDB Entry DOI: 10.7270/Q2KP81XB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1/2 (Homo sapiens (Human)) | BDBM50163251 (2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre Curated by ChEMBL | Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis | Eur J Med Chem 144: 859-873 (2018) Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1/2 (Homo sapiens (Human)) | BDBM50163251 (2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre Curated by ChEMBL | Assay Description Inhibition of Chk2 (unknown origin) assessed as decrease in Cdc25C phosphorylation at Ser216 by ELISA based spectrophotometric analysis | Eur J Med Chem 146: 687-708 (2018) Article DOI: 10.1016/j.ejmech.2018.01.072 BindingDB Entry DOI: 10.7270/Q2TQ643K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1/2 (Homo sapiens (Human)) | BDBM50163251 (2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre Curated by ChEMBL | Assay Description Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis | Eur J Med Chem 134: 392-405 (2017) Article DOI: 10.1016/j.ejmech.2017.03.090 BindingDB Entry DOI: 10.7270/Q27P91T8 | |||||||||||
More data for this Ligand-Target Pair |