| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50292244 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1731712 (CHEMBL4147248) |
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| IC50 | 35±n/a nM |
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| Citation |  Long, L; Luo, Y; Hou, ZJ; Ma, HJ; Long, ZJ; Tu, ZC; Huang, LJ; Liu, Q; Lu, G Synthesis and biological evaluation of aurora kinases inhibitors based on N-trisubstituted pyrimidine scaffold. Eur J Med Chem145:805-812 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50292244 |
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| n/a |
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| Name | BDBM50292244 |
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| Synonyms: | CHEMBL4175359 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19ClFN7O |
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| Mol. Mass. | 403.841 |
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| SMILES | Cc1cc(Nc2cc(nc(Nc3ccc(F)c(Cl)c3)n2)N2CCOCC2)n[nH]1 |
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| Structure | 
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