| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Ligand | BDBM50314859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1733219 (CHEMBL4148755) |
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| Ki | 460±n/a nM |
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| Citation |  Abou Samra, A; Robert, A; Gov, C; Favre, L; Eloy, L; Jacquet, E; Bignon, J; Wiels, J; Desrat, S; Roussi, F Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur J Med Chem148:26-38 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Synonyms: | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1 |
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| Type: | Developmental protein |
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| Mol. Mass.: | 35215.08 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 331 |
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| Sequence: | MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARP
PPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA
VLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPL
GEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVT
NWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFF
HVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50314859 |
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| n/a |
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| Name | BDBM50314859 |
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| Synonyms: | CHEMBL4169123 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29BrClNO6 |
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| Mol. Mass. | 614.911 |
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| SMILES | [H][C@]12C[C@H](CCOC(=O)Nc3ccc(Br)cc3)C=C[C@]1([C@H](\C=C(/Cl)c1ccc(cc1)C(O)=O)C=C(C)C2)C(O)=O |r,c:18,t:36| |
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| Structure | 
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