Reaction Details | |||
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | ||
Ligand | BDBM50314866 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1733219 (CHEMBL4148755) | ||
Ki | 5200±n/a nM | ||
Citation | Abou Samra, A; Robert, A; Gov, C; Favre, L; Eloy, L; Jacquet, E; Bignon, J; Wiels, J; Desrat, S; Roussi, F Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. Eur J Med Chem148:26-38 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | |||
Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | ||
Synonyms: | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1 | ||
Type: | Developmental protein | ||
Mol. Mass.: | 35215.08 | ||
Organism: | Mus musculus (Mouse) | ||
Description: | n/a | ||
Residue: | 331 | ||
Sequence: |
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BDBM50314866 | |||
n/a | |||
Name | BDBM50314866 | ||
Synonyms: | CHEMBL4161959 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H44O4 | ||
Mol. Mass. | 468.668 | ||
SMILES | [H][C@@]1(C[C@]2([H])CC(C)=C[C@@H](\C=C(/C)[C@H]3CCC(CC3)C(O)=O)[C@@]2(C=C1)C(O)=O)[C@@H](C)CCC=C(C)C |r,wU:1.0,28.31,wD:3.3,9.9,13.12,22.27,c:7,25,(10.46,-2.76,;10.48,-4.31,;9.14,-3.52,;7.81,-4.3,;7.8,-2.76,;6.48,-3.51,;5.15,-4.3,;3.82,-3.53,;5.15,-5.84,;6.48,-6.59,;6.49,-8.13,;5.15,-8.91,;3.82,-8.14,;5.15,-10.45,;3.81,-11.21,;3.81,-12.74,;5.14,-13.52,;6.48,-12.75,;6.49,-11.2,;5.14,-15.06,;3.8,-15.82,;6.47,-15.83,;7.81,-5.84,;9.13,-6.6,;10.47,-5.85,;8.2,-7.31,;7.42,-8.64,;9.74,-7.31,;11.81,-3.54,;11.82,-2,;13.14,-4.32,;14.48,-3.55,;15.81,-4.33,;17.15,-3.57,;18.48,-4.35,;17.16,-2.03,)| | ||
Structure |