Reaction Details |
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Target | Sodium-dependent phosphate transporter 1 |
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Ligand | BDBM50341385 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1734218 (CHEMBL4149754) |
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IC50 | >25000±n/a nM |
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Citation | Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent phosphate transporter 1 |
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Name: | Sodium-dependent phosphate transporter 1 |
Synonyms: | GLVR-1 | GLVR1 | Gibbon ape leukemia virus receptor 1 | Leukemia virus receptor 1 homolog | PIT1 | Phosphate transporter 1 | PiT-1 | S20A1_HUMAN | SLC20A1 | Sodium-dependent phosphate transporter 1 | Solute carrier family 20 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 73702.88 |
Organism: | Homo sapiens |
Description: | ChEMBL_118154 |
Residue: | 679 |
Sequence: | MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLK
QACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVA
SFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLV
RAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAV
FCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSE
VGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLV
QFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTS
YTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEI
DMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIG
PLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGF
SIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPI
SGVISAAIMAIFRYVILRM
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BDBM50341385 |
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n/a |
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Name | BDBM50341385 |
Synonyms: | CHEMBL4161567 |
Type | Small organic molecule |
Emp. Form. | C18H17ClF3N5O |
Mol. Mass. | 411.809 |
SMILES | Cc1[nH]c2c(N3CCC4(CCNC4=O)CC3)c(C#N)c(nc2c1Cl)C(F)(F)F |
Structure |
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