| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent phosphate transport protein 2A |
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| Ligand | BDBM50327355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1734226 (CHEMBL4149762) |
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| Ki | 2000±n/a nM |
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| Citation |  Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent phosphate transport protein 2A |
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| Name: | Sodium-dependent phosphate transport protein 2A |
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| Synonyms: | NPT2 | NPT2A_HUMAN | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-3 | SLC17A2 | SLC34A1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68955.19 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116742 |
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| Residue: | 639 |
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| Sequence: | MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEH
TCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDM
LSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLE
VSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAA
TGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHS
LIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLV
LLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSS
VFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFF
NISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQV
MVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCC
ARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
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| BDBM50327355 |
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| n/a |
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| Name | BDBM50327355 |
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| Synonyms: | CHEMBL4164691 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F3N5O |
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| Mol. Mass. | 377.3636 |
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| SMILES | Cc1cc2nc(c(C#N)c(N3CCC4(CCNC4=O)CC3)c2[nH]1)C(F)(F)F |
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| Structure | 
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