| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent phosphate transporter 1 |
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| Ligand | BDBM50327356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1734218 (CHEMBL4149754) |
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| IC50 | >14000±n/a nM |
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| Citation |  Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett9:440-445 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent phosphate transporter 1 |
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| Name: | Sodium-dependent phosphate transporter 1 |
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| Synonyms: | GLVR-1 | GLVR1 | Gibbon ape leukemia virus receptor 1 | Leukemia virus receptor 1 homolog | PIT1 | Phosphate transporter 1 | PiT-1 | S20A1_HUMAN | SLC20A1 | Sodium-dependent phosphate transporter 1 | Solute carrier family 20 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73702.88 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118154 |
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| Residue: | 679 |
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| Sequence: | MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLK
QACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVA
SFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLV
RAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAV
FCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSE
VGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLV
QFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTS
YTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEI
DMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIG
PLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGF
SIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPI
SGVISAAIMAIFRYVILRM
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| BDBM50327356 |
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| n/a |
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| Name | BDBM50327356 |
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| Synonyms: | CHEMBL4172584 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F3N6 |
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| Mol. Mass. | 400.4003 |
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| SMILES | Cc1cc2nc(c(C#N)c(N3CCC(CC3)Nc3ccccn3)c2[nH]1)C(F)(F)F |
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| Structure | 
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