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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 8 | ||
| Ligand | BDBM50366670 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1735496 (CHEMBL4151032) | ||
| Kd | >5000±n/a nM | ||
| Citation |  Zhao, Y; Zhou, B; Bai, L; Liu, L; Yang, CY; Meagher, JL; Stuckey, JA; McEachern, D; Przybranowski, S; Wang, M; Ran, X; Aguilar, A; Hu, Y; Kampf, JW; Li, X; Zhao, T; Li, S; Wen, B; Sun, D; Wang, S Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem61:6110-6120 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 8 | |||
| Name: | Bromodomain-containing protein 8 | ||
| Synonyms: | BRD8 | BRD8_HUMAN | Bromodomain-containing protein 8 | SMAP | SMAP | SMAP2 | Skeletal muscle abundant protein | Skeletal muscle abundant protein 2 | Thyroid hormone receptor coactivating protein of 120 kDa | TrCP120 | p120 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 135233.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_109820 | ||
| Residue: | 1235 | ||
| Sequence: |
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| BDBM50366670 | |||
| n/a | |||
| Name | BDBM50366670 | ||
| Synonyms: | CHEMBL4173488 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25N7O2 | ||
| Mol. Mass. | 443.501 | ||
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21 |(86.87,-46.33,;85.61,-45.43,;84.21,-46.07,;84.06,-47.6,;82.66,-48.24,;81.41,-47.34,;81.56,-45.82,;82.95,-45.18,;83.09,-43.65,;81.94,-42.63,;80.43,-42.97,;82.55,-41.22,;84.08,-41.36,;84.42,-42.87,;85.83,-43.48,;80.17,-48.26,;80.66,-49.73,;79.89,-51.06,;80.66,-52.39,;79.89,-53.73,;82.21,-52.4,;82.97,-51.06,;84.51,-51.06,;85.28,-52.39,;84.66,-53.8,;85.81,-54.83,;87.14,-54.06,;86.82,-52.56,;87.85,-51.41,;85.64,-56.36,;84.75,-57.61,;86.28,-57.77,;82.2,-49.71,)| | ||
| Structure | 
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