Reaction Details |
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Target | Sphingomyelin phosphodiesterase |
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Ligand | BDBM50221662 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1737276 (CHEMBL4153026) |
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IC50 | 14700±n/a nM |
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Citation | Yang, K; Nong, K; Gu, Q; Dong, J; Wang, J Discovery of N-hydroxy-3-alkoxybenzamides as direct acid sphingomyelinase inhibitors using a ligand-based pharmacophore model. Eur J Med Chem151:389-400 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingomyelin phosphodiesterase |
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Name: | Sphingomyelin phosphodiesterase |
Synonyms: | 3.1.4.12 | ASM | ASM_HUMAN | Acid sphingomyelinase | SMPD1 | Sphingomyelin phosphodiesterase | aSMase |
Type: | PROTEIN |
Mol. Mass.: | 69945.03 |
Organism: | Homo sapiens |
Description: | ChEMBL_11570 |
Residue: | 631 |
Sequence: | MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE
AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK
LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL
PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT
VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL
RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR
ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
ARADSPALCRHLMPDGSLPEAQSLWPRPLFC
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BDBM50221662 |
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n/a |
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Name | BDBM50221662 |
Synonyms: | CHEMBL320658 |
Type | Small organic molecule |
Emp. Form. | C19H20O7 |
Mol. Mass. | 360.3579 |
SMILES | [#6]-[#8]-c1c(-[#8])cc(-[#8])c(-[#6](=O)-c2c(-[#8])cc(-[#8])cc2-[#8])c1-[#6]\[#6]=[#6](/[#6])-[#6] |
Structure |
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