| Reaction Details |
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 | Report a problem with these data |
| Target | Sensory histidine kinase DcuS |
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| Ligand | BDBM50406468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1738855 (CHEMBL4154605) |
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| IC50 | 608±n/a nM |
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| Citation |  Hansen, AM; Peng, P; Baldry, M; Perez-Gassol, I; Christensen, SB; Vinther, JMO; Ingmer, H; Franzyk, H Lactam hybrid analogues of solonamide B and autoinducing peptides as potent S. aureus AgrC antagonists. Eur J Med Chem152:370-376 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sensory histidine kinase DcuS |
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| Name: | Sensory histidine kinase DcuS |
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| Synonyms: | Receptor-histidine kinase AgrC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49890.25 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_305973 |
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| Residue: | 430 |
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| Sequence: | MELLNSYNFVLFVLTQMILMFTIPAIISGIKYSKLDYFFIIVISTLSLFLFKMFDSASLI
ILTSFIIIMYFVKIKWYSILLIMTSQIILYCANYMYIVIYAYITKISDSIFVIFPSFFVV
YVTISILFSYIINRVLKKISTPYLILNKGFLIVISTILLLTFSLFFFYSQINSDEAKVIR
QYSFIFIGITIFLSILTFVISQFLLKEMKYKRNQEEIETYYEYTLKIEAINNEMRKFRHD
YVNILTTLSEYIREDDMPGLRDYFNKNIVPMKDNLQMNAIKLNGIENLKVREIKGLITAK
ILRAQEMNIPISIEIPDEVSSINLNMIDLSRSIGIILDNAIEASTEIDDPIIRVAFIESE
NSVTFIVMNKCADDIPRIHELFQESFSTKGEGRGLGLSTLKEIADNADNVLLDTIIENGF
FIQKVEIINN
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| BDBM50406468 |
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| n/a |
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| Name | BDBM50406468 |
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| Synonyms: | CHEMBL4169564 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H56N6O6 |
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| Mol. Mass. | 656.8557 |
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| SMILES | CCCCCCC(=O)N[C@@H]1CNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC1=O |r| |
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| Structure | 
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