| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50018478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54744 (CHEMBL667195) |
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| Ki | 0.500000±n/a nM |
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| Citation |  Roth, B; Tidwell, MY; Ferone, R; Baccanari, DP; Sigel, CW; DeAngelis, D; Elwell, LP 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. J Med Chem32:1949-58 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
|
|
|
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| BDBM50018478 |
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| n/a |
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| Name | BDBM50018478 |
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| Synonyms: | 5-(3-Ethoxy-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL23609 | TCMDC-137664 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N4O3 |
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| Mol. Mass. | 304.3443 |
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| SMILES | CCOc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
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| Structure | 
|
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