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TargetHydroxymethylglutaryl-CoA synthase, cytoplasmic
LigandBDBM50014354
Substrate/Competitorn/a
Meas. Tech.ChEBML_78360
IC50 43±n/a nM
Citation Balasubramanian, N; Brown, PJ; Catt, JD; Han, WT; Parker, RA; Sit, SY; Wright, JJ A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase. J Med Chem32:2038-41 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Name:Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Synonyms:3-hydroxy-3-methylglutaryl coenzyme A synthase | HMCS1_RAT | HMG-CoA synthase | Hmgcs | Hmgcs1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Type:PROTEIN
Mol. Mass.:57428.09
Organism:Rattus norvegicus
Description:ChEMBL_78360
Residue:520
Sequence:
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCT
DREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDI
EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALL
IGPNAPVIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKI
RAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEA
FGDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAP
DVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPSTNDHSLDEG
VGLVHSNTATEHIPSPAKKVPRLPATSGEPESAVISNGEH
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  Blast E-value cutoff:
BDBM50014354
n/a
NameBDBM50014354
Synonyms:6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetrazol-5-yl)-buta-1,3-dienyl]-4-hydroxy-tetrahydro-pyran-2-one | 6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetrazol-5-yl)-buta-1,3-dienyl]-4-hydroxy-tetrahydro-pyran-2-one (BMY 22089) | BMY-22089 | CHEMBL60218
TypeSmall organic molecule
Emp. Form.C23H20F2N4O3
Mol. Mass.438.4267
SMILES[#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6@@H]-1-[#6]-[#6@@H](-[#8])-[#6]-[#6](=O)-[#8]1)=[#6](/c1ccc(F)cc1)-c1ccc(F)cc1
Structure
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