| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 4 |
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| Ligand | BDBM101536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739967 (CHEMBL4155717) |
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| IC50 | 18±n/a nM |
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| Citation |  Guo, J; Zhao, F; Yin, W; Zhu, M; Hao, C; Pang, Y; Wu, T; Wang, J; Zhao, D; Li, H; Cheng, M Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors. Eur J Med Chem155:197-209 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 4 |
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| Name: | Serine/threonine-protein kinase PAK 4 |
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| Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) |
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| Type: | Protein |
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| Mol. Mass.: | 64098.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96013 |
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| Residue: | 591 |
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| Sequence: | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
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| BDBM101536 |
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| n/a |
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| Name | BDBM101536 |
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| Synonyms: | CHEMBL3128043 | US8530494, 203 | US8530652, 114 | US8530652, 63 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N8OS |
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| Mol. Mass. | 490.624 |
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| SMILES | CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)[nH]nc2C1(C)C)c1ccccc1 |r| |
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| Structure | 
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