| Reaction Details |
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 | Report a problem with these data |
| Target | Relaxin receptor 1 |
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| Ligand | BDBM50449860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1740775 (CHEMBL4156525) |
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| EC50 | 94±n/a nM |
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| Citation |  Wilson, KJ; Xiao, J; Chen, CZ; Huang, Z; Agoulnik, IU; Ferrer, M; Southall, N; Hu, X; Zheng, W; Xu, X; Wang, A; Myhr, C; Barnaeva, E; George, ER; Agoulnik, AI; Marugan, JJ Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem156:79-92 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Relaxin receptor 1 |
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| Name: | Relaxin receptor 1 |
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| Synonyms: | LGR7 | Leucine-rich repeat-containing G-protein coupled receptor 7 | RXFP1 | RXFP1_HUMAN | Relaxin family peptide receptor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86990.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_818426 |
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| Residue: | 757 |
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| Sequence: | MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED
NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA
VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY
LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK
PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL
DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ
RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC
FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM
ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF
IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG
SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT
ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV
EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
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| BDBM50449860 |
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| n/a |
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| Name | BDBM50449860 |
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| Synonyms: | CHEMBL3716980 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N2O5S |
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| Mol. Mass. | 506.494 |
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| SMILES | CC(C)Oc1ccccc1C(=O)Nc1ccccc1C(=O)Nc1cccc(c1)S(=O)(=O)C(F)(F)F |
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| Structure | 
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