| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-arginine deiminase type-2 |
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| Ligand | BDBM50450898 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1744059 (CHEMBL4178569) |
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| EC50 | 1200±n/a nM |
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| Citation |  Muth, A; Subramanian, V; Beaumont, E; Nagar, M; Kerry, P; McEwan, P; Srinath, H; Clancy, K; Parelkar, S; Thompson, PR Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem60:3198-3211 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-arginine deiminase type-2 |
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| Name: | Protein-arginine deiminase type-2 |
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| Synonyms: | KIAA0994 | PAD-H19 | PAD2 | PADI2 | PADI2_HUMAN | PDI2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75552.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290379 |
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| Residue: | 665 |
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| Sequence: | MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP
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| BDBM50450898 |
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| n/a |
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| Name | BDBM50450898 |
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| Synonyms: | CHEMBL4204476 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26ClN5O |
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| Mol. Mass. | 459.971 |
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| SMILES | ClCC(=N)NCCC[C@H](NC(=O)c1ccc(cc1)-c1ccccc1)c1nc2ccccc2[nH]1 |r| |
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| Structure | 
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