| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein-arginine deiminase type-2 |
|---|
| Ligand | BDBM50450899 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1744057 (CHEMBL4178567) |
|---|
| EC50 | 9500±n/a nM |
|---|
| Citation |  Muth, A; Subramanian, V; Beaumont, E; Nagar, M; Kerry, P; McEwan, P; Srinath, H; Clancy, K; Parelkar, S; Thompson, PR Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem60:3198-3211 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein-arginine deiminase type-2 |
|---|
| Name: | Protein-arginine deiminase type-2 |
|---|
| Synonyms: | KIAA0994 | PAD-H19 | PAD2 | PADI2 | PADI2_HUMAN | PDI2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 75552.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1290379 |
|---|
| Residue: | 665 |
|---|
| Sequence: | MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP
|
|
|
|---|
| BDBM50450899 |
|---|
| n/a |
|---|
| Name | BDBM50450899 |
|---|
| Synonyms: | CHEMBL4214962 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27FN6O3 |
|---|
| Mol. Mass. | 466.508 |
|---|
| SMILES | COc1cccc2n(C)c(nc12)[C@H](CCCNC(=N)CF)NC(=O)c1cccc2CNC(=O)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
