| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM50249030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1745592 (CHEMBL4180102) |
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| EC50 | 225±n/a nM |
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| Citation |  Long, MF; Engers, JL; Chang, S; Zhan, X; Weiner, RL; Luscombe, VB; Rodriguez, AL; Cho, HP; Niswender, CM; Bridges, TM; Conn, PJ; Engers, DW; Lindsley, CW Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M Bioorg Med Chem Lett27:4999-5001 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52841.70 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
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| Residue: | 477 |
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| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM50249030 |
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| n/a |
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| Name | BDBM50249030 |
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| Synonyms: | CHEMBL3770346 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14ClN3O2S |
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| Mol. Mass. | 311.787 |
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| SMILES | COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl |
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| Structure | 
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