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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50451607
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1745955 (CHEMBL4180465)
EC50 7.0±n/a nM
Citation Cook, J; Zusi, FC; Hill, MD; Fang, H; Pearce, B; Park, H; Gallagher, L; McDonald, IM; Bristow, L; Macor, JE; Olson, RE Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor. Bioorg Med Chem Lett27:5002-5005 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:Enzyme
Mol. Mass.:56502.44
Organism:Rattus norvegicus (Rat)
Description:Q05941
Residue:502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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BDBM50451607
n/a
NameBDBM50451607
Synonyms:CHEMBL4202588
TypeSmall organic molecule
Emp. Form.C16H19N3O
Mol. Mass.269.3416
SMILESCc1cccc2n3C[C@@]4(CN5CCC4CC5)Oc3nc12 |r,wU:8.17,THB:16:8:11.12:15.14,(20.88,-18.07,;20.47,-19.64,;21.57,-20.72,;21.18,-22.21,;19.7,-22.62,;18.6,-21.53,;17.07,-21.62,;15.87,-22.59,;14.59,-21.76,;14.89,-23.22,;13.45,-22.56,;11.84,-23.25,;11.62,-21.8,;13.18,-21.12,;13.24,-19.4,;13.72,-20.57,;14.98,-20.27,;16.51,-20.19,;17.7,-19.21,;18.99,-20.05,)|
Structure
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