| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
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| Ligand | BDBM40726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1746765 (CHEMBL4181275) |
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| IC50 | 42390±n/a nM |
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| Citation |  Wang, WL; Chen, XY; Gao, Y; Gao, LX; Sheng, L; Zhu, J; Xu, L; Ding, ZZ; Zhang, C; Li, JY; Li, J; Zhou, YB Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors. Bioorg Med Chem Lett27:5154-5157 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
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| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 68443.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06124 |
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| Residue: | 593 |
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| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| BDBM40726 |
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| n/a |
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| Name | BDBM40726 |
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| Synonyms: | (6-bromopiazthiol-5-yl)amine | 5-bromanyl-2,1,3-benzothiadiazol-6-amine | 5-bromo-2,1,3-benzothiadiazol-6-amine | 6-Bromo-benzo[1,2,5]thiadiazol-5-ylamine | MLS000556153 | SMR000174162 | cid_3096032 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H4BrN3S |
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| Mol. Mass. | 230.085 |
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| SMILES | Nc1cc2nsnc2cc1Br |
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| Structure | 
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