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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-type tyrosine-protein kinase FLT3 | ||
| Ligand | BDBM50453194 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1749251 (CHEMBL4183761) | ||
| IC50 | 3.0±n/a nM | ||
| Citation |  Gucký, T; ?ezní?ková, E; Rado?ová Muchová, T; Jorda, R; Klejová, Z; Malínková, V; Berka, K; Bazgier, V; Ajani, H; Lep?ík, M; Divoký, V; Kry?tof, V Discovery of N J Med Chem61:3855-3869 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-type tyrosine-protein kinase FLT3 | |||
| Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
| Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 112888.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36888 | ||
| Residue: | 993 | ||
| Sequence: |
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| BDBM50453194 | |||
| n/a | |||
| Name | BDBM50453194 | ||
| Synonyms: | CHEMBL4204373 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H38N8O | ||
| Mol. Mass. | 490.6436 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 |r,wU:4.7,wD:1.0,(23.34,-10.58,;22.01,-11.35,;20.68,-10.58,;19.34,-11.35,;19.34,-12.89,;20.68,-13.66,;22.01,-12.89,;18.01,-13.66,;18.01,-15.2,;19.34,-15.97,;19.34,-17.51,;20.68,-18.28,;22.01,-17.51,;22.01,-15.97,;23.34,-15.2,;24.68,-15.97,;26.01,-15.2,;27.34,-15.97,;28.68,-15.2,;30.01,-15.97,;30.01,-17.51,;28.68,-18.28,;27.34,-17.51,;24.68,-17.51,;23.34,-18.28,;18.01,-18.28,;17.69,-19.79,;16.16,-19.95,;15.53,-18.54,;14.02,-18.22,;12.88,-19.25,;11.55,-18.48,;11.87,-16.98,;13.4,-16.82,;16.67,-17.51,;16.67,-15.97,)| | ||
| Structure | 
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