Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone acetyltransferase KAT2A | ||
| Ligand | BDBM179481 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1750699 (CHEMBL4185459) | ||
| Kd | >4000±n/a nM | ||
| Citation |  Zhao, Y; Bai, L; Liu, L; McEachern, D; Stuckey, JA; Meagher, JL; Yang, CY; Ran, X; Zhou, B; Hu, Y; Li, X; Wen, B; Zhao, T; Li, S; Sun, D; Wang, S Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J Med Chem60:3887-3901 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone acetyltransferase KAT2A | |||
| Name: | Histone acetyltransferase KAT2A | ||
| Synonyms: | GCN5 | GCN5 | GCN5L2 | General control of amino acid synthesis protein 5-like 2 | HGCN5 | Histone acetyltransferase GCN5 | Histone acetyltransferase KAT2A | Histone acetyltransferase KAT2A/KAT2B | HsGCN5 | KAT2A | KAT2A_HUMAN | Lysine acetyltransferase 2A | STAF97 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 93956.22 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_100876 | ||
| Residue: | 837 | ||
| Sequence: |
| ||
| BDBM179481 | |||
| n/a | |||
| Name | BDBM179481 | ||
| Synonyms: | US9675697, Cpd. No. 73 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H21N5O2 | ||
| Mol. Mass. | 435.4772 | ||
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c21 |(-1.5,3.22,;-2.13,1.81,;-1.36,.48,;.18,.48,;.95,-.85,;.18,-2.19,;-1.36,-2.19,;-2.13,-.85,;-3.67,-.85,;-4.57,-2.1,;-4.18,-3.59,;-6.04,-1.62,;-6.04,-.08,;-4.57,.39,;-4.18,1.88,;1.21,-3.33,;2.62,-2.71,;4.03,-3.33,;5.27,-2.43,;6.68,-3.05,;5.11,-.9,;3.7,-.27,;3.31,1.22,;1.84,1.69,;1.52,3.2,;2.66,4.23,;4.13,3.75,;5.27,4.79,;6.74,4.31,;7.06,2.8,;5.91,1.77,;4.45,2.25,;2.46,-1.17,)| | ||
| Structure | 
| ||