| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin |
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| Ligand | BDBM50134315 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1750753 (CHEMBL4185513) |
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| IC50 | 510±n/a nM |
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| Citation |  Buuh, ZY; Lyu, Z; Wang, RE Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem61:3239-3252 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin |
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| Name: | E3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin |
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| Synonyms: | Sharpin/RBCK1/RNF31 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1750753 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Sharpin |
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| Synonyms: | SHARPIN | SHRPN_HUMAN | SIPL1 | Shank-associated RH domain-interacting protein | Shank-interacting protein-like 1 | hSIPL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39944.77 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118340 |
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| Residue: | 387 |
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| Sequence: | MAPPAGGAAAAASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLEL
LGAGPGAVNLEWPLESVSYTIRGPTQHELQPPPGGPGTLSLHFLNPQEAQRWAVLVRGAT
VEGQNGSKSNSPPALGPEACPVSLPSPPEASTLKGPPPEADLPRSPGNLTEREELAGSLA
RAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHV
ALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLL
SAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGPQPAASSLPSPLQPSWSCPSCTFI
NAPDRPGCEMCSTQRPCTWDPLAAAST
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| Component 2 |
| Name: | RanBP-type and C3HC4-type zinc finger-containing protein 1 |
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| Synonyms: | 2.3.2.31 | C20orf18 | HBV-associated factor 4 | HOIL-1 | HOIL1_HUMAN | Heme-oxidized IRP2 ubiquitin ligase 1 | Hepatitis B virus X-associated protein 4 | RBCK1 | RING finger protein 54 | RING-type E3 ubiquitin transferase HOIL-1 | RNF54 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | UBCE7IP3 | Ubiquitin-conjugating enzyme 7-interacting protein 3 | XAP3 | XAP4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57563.56 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118340 |
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| Residue: | 510 |
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| Sequence: | MDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKPEVSPTQDIRLWVS
VEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVR
QNGDSAYLYLLSARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQE
PGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVPASYQPDEEERARL
AGEEEALRQYQQRKQQQQEGNYLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLREC
LHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISI
AENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNCKEYQEDLAL
RAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGCDWIRCTVCHTEICWVTKGPR
WGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
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| Component 3 |
| Name: | E3 ubiquitin-protein ligase RNF31 |
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| Synonyms: | 2.3.2.31 | E3 ubiquitin-protein ligase RNF31 | HOIL-1-interacting protein | HOIP | RING finger protein 31 | RING-type E3 ubiquitin transferase RNF31 | RNF31 | RNF31_HUMAN | ZIBRA | Zinc in-between-RING-finger ubiquitin-associated domain protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119651.81 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118340 |
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| Residue: | 1072 |
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| Sequence: | MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPLAARYLQLDAARLVRCN
AHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNNPVFRSTVDAVQGGRDVLR
LYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTELSLLLQNTHPRQQALEQLLED
KVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCFLCGSAPGTLHCPSCKQALCPAC
DHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASA
HLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCT
FENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQVWYCIHCTF
CNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPPKPGPPRRLSAPLPSSCGDPEKQR
QDKMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAG
QQDPGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQ
HGGDVSRALTELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAE
LALSLLQETPRNYELGDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECT
ICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYAL
FHKKLTEGVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRS
CEDFQNWKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSG
CYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAG
ARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATL
YEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK
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| BDBM50134315 |
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| n/a |
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| Name | BDBM50134315 |
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| Synonyms: | 7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione | CHEMBL331627 | GLIOTOXIN |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14N2O4S2 |
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| Mol. Mass. | 326.391 |
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| SMILES | CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20| |
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| Structure | 
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