| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK4 |
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| Ligand | BDBM50453821 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1750888 (CHEMBL4185648) |
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| IC50 | 82±n/a nM |
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| Citation |  Ferguson, FM; Doctor, ZM; Chaikuad, A; Sim, T; Kim, ND; Knapp, S; Gray, NS Characterization of a highly selective inhibitor of the Aurora kinases. Bioorg Med Chem Lett27:4405-4408 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK4 |
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| Name: | Serine/threonine-protein kinase PLK4 |
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| Synonyms: | PLK4 | PLK4_HUMAN | Polo-Like Kinase 4 | SAK | STK18 | Serine/threonine-protein kinase PLK4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108996.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1474078 |
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| Residue: | 970 |
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| Sequence: | MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRV
IQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERY
SPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWF
GNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQ
NTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLK
PIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLA
DRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPG
ADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICL
ALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMH
SAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWAT
QLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL
MFSNPTPNFH
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| BDBM50453821 |
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| n/a |
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| Name | BDBM50453821 |
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| Synonyms: | CHEMBL4206831 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29N7O3 |
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| Mol. Mass. | 535.5964 |
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| SMILES | CCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2ncc3N(C)C(=O)c4cc(C)ccc4N(C)c3n2)cc1 |
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| Structure | 
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