| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin alpha-1A chain |
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| Ligand | BDBM50020469 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211863 |
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| IC50 | 16000±n/a nM |
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| Citation |  Kruse, LI; Ladd, DL; Harrsch, PB; McCabe, FL; Mong, SM; Faucette, L; Johnson, R Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues. J Med Chem32:409-17 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin alpha-1A chain |
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| Name: | Tubulin alpha-1A chain |
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| Synonyms: | TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain |
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| Type: | Protein |
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| Mol. Mass.: | 50049.25 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P02550 |
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| Residue: | 451 |
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| Sequence: | MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
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| BDBM50020469 |
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| n/a |
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| Name | BDBM50020469 |
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| Synonyms: | CHEMBL134616 | {5-[4-(2,2,2-Trifluoro-acetyl)-thiophene-2-carbonyl]-1H-benzoimidazol-2-yl}-carbamic acid methyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10F3N3O4S |
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| Mol. Mass. | 397.329 |
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| SMILES | COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1cc(cs1)C(=O)C(F)(F)F |
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| Structure | 
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