| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 4 |
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| Ligand | BDBM50455023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1753700 (CHEMBL4188460) |
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| IC50 | 3700±n/a nM |
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| Citation |  Xu, Q; Kulkarni, AA; Sajith, AM; Hussein, D; Brown, D; Güner, OF; Reddy, MD; Watkins, EB; Lassègue, B; Griendling, KK; Bowen, JP Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4. Bioorg Med Chem26:989-998 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 4 |
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| Name: | NADPH oxidase 4 |
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| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66954.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792879 |
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| Residue: | 578 |
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| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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| BDBM50455023 |
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| n/a |
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| Name | BDBM50455023 |
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| Synonyms: | CHEMBL4204145 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F4N2O3S |
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| Mol. Mass. | 402.363 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)N1CCCN(C1=O)c1ccc(cc1)C(F)(F)F |
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| Structure | 
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